it might go away. do you keep the window open? that helped my dog a lot. she would get sick exactly 45 minutes into any car ride. seriously, it was like clockwork (and we always drove from VA to NY so thats no fun). she probably grew out of it around 4 or 5 years old. after we learned that she HAD to have the windows down.
you can try making him lay down, if he's wandering around, he might be losing his balance which isnt helping with the car sickness. also, there is meds you can give, but talk to your vet about that because its all based on size/weight
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